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Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H Y Loh, L Miguel Martins
Apr 17, 2023
Parkinson's disease (PD) is characterised by selective death of dopaminergic (DA) neurons in the midbrain and motor function impairment. Gastrointestinal issues often precede motor deficits in PD, indicating that the gut-brain...
Animals Drosophila Drosophila melanogaster Parkinson Disease Drosophila Proteins Unfolded Protein Response Protein Serine-Threonine Kinases
Published by: Cell Death & Disease
Parthenogenesis in dipterans
Parthenogenesis has been documented in almost every phylum of animals, and yet this phenomenon is largely understudied. It has particular importance in dipterans since some parthenogenetic species are also disease vectors and...
development Drosophila Reproduction parthenogenesis dipterans Animals Drosophila melanogaster agriculture
Published by: Proceedings. Biological sciences